Figure 4 - T- and B- cell dynamics#

[1]:
from tdm.publications.first.figures.f4 import fig_4abc, fig_4d, fig_4e, fig_4f, fig_4g

Fig 4A,B,C: T- and B- cell Phase portrait (left), T-cell growth (middle) and B-cell growth (right)#

[2]:
fig_4abc()
../../_images/notebooks_paper_figures_Figure-04_3_0.png

Fig 4D: The TB circuit is excitable: if T cell density crosses a threshold T and B exhibit a pulse#

[3]:
fig_4d()
100%|██████████| 2000/2000 [01:07<00:00, 29.44it/s]
../../_images/notebooks_paper_figures_Figure-04_5_1.png

Fig 4F: The TB circuit has a refractory period in which new pulses cannot be triggered#

[4]:
fig_4e()
100%|██████████| 1000/1000 [01:17<00:00, 12.95it/s]
100%|██████████| 1500/1500 [00:19<00:00, 76.53it/s]
100%|██████████| 1000/1000 [01:28<00:00, 11.27it/s]
../../_images/notebooks_paper_figures_Figure-04_7_1.png

Fig 4F: OSDR 3D model of CD4, CD8 and B-cell dynamics exhibits a pulse when CD4 T cell density crosses threshold#

[5]:
fig_4f()
../../_images/notebooks_paper_figures_Figure-04_9_0.png

Fig 4G: Adaptive immune cells proliferate in high densities of CD4 T-cells and low densities of B-cells#

[6]:
fig_4g()
../../_images/notebooks_paper_figures_Figure-04_11_0.png
../../_images/notebooks_paper_figures_Figure-04_11_1.png
../../_images/notebooks_paper_figures_Figure-04_11_2.png