Figure 3 - Fibroblast Macrophage Dynamics#

[1]:

from tdm.publications.first.figures.f3 import fig_3a, fig_3def, fig_3g, fig_3h

Fig 3A: Neighbor cell counts are strong predictors of division probability#

[2]:

fig_3a()

1/5 Constructing tissues [V]
2/5 Counting cell-neighbors [V]
3/5 Filtering cell-types [V]
4/5 Transforming features [V]
5/5 Fitting a model [V]
../../_images/notebooks_paper_figures_Figure-03_3_1.png

Fig 3D,E,F:#

  • Fibroblast-Macrophage Phase portrait (left)

  • Fibroblast growth rate (middle)

  • Macrophage growth rate (right)

[3]:

fig_3def()
../../_images/notebooks_paper_figures_Figure-03_5_0.png

Fig 3G: Tumor-cells support the hot-fibrosis fixed-point#

[4]:

fig_3g()
../../_images/notebooks_paper_figures_Figure-03_7_0.png

Hot Fibrosis is associated with poor prognosis#

[5]:

fig_3h()

Median survival time for hot-fibrosis: 132.566666666667
Median survival time for cold-fibrosis: 192.266666666667
../../_images/notebooks_paper_figures_Figure-03_9_1.png